Paper-based assays: a success of the engineering design and the convergence of knowledge areas

Lab Chip, 2016, Accepted ManuscriptDOI: 10.1039/C6LC00737F, Tutorial ReviewAdaris Lopez_Marzo, Arben MerkociThis review shows the recent advances and state-of-the-art in paper-based analytical devices (PADs) through the analysis of their integration wi…

Standalone ethanol micro-reformer integrated on silicon technology for onboard production of hydrogen-rich gas

Lab Chip, 2016, Accepted ManuscriptDOI: 10.1039/C6LC00583G, PaperDolors Pla, Marc Salleras, Alex Morata, Inigo Garbayo, Marta Gerboles, Neus Sabate, Nuria J. Divins, Albert Casanovas, Jordi Llorca, Albert TaranconA novel design of a silicon-based micro…

Standard Reticle Slide To Objectively Evaluate Spatial Resolution and Instrument Performance in Imaging Mass Spectrometry

Analytical ChemistryDOI: 10.1021/acs.analchem.6b01655

Ionic Liquids as a Reference Material Candidate for the Quick Performance Check of Energy Dispersive X-ray Spectrometers for the Low Energy Range below 1 keV

Analytical ChemistryDOI: 10.1021/acs.analchem.6b01444

Development of Quantitative Radioactive Methodologies on Paper to Determine Important Lateral-Flow Immunoassay Parameters

Lab Chip, 2016, Accepted ManuscriptDOI: 10.1039/C6LC00518G, PaperGarrett Lee Mosley, Phuong T Nguyen, Benjamin Wu, Daniel KameiThe lateral-flow immunoassay (LFA) is a well-established diagnostic technology that has recently seen significant advancement…

Integrative volumetric bar-chart chip for rapid and quantitative point-of-care detection of myocardial infarction biomarkers

Lab Chip, 2016, Accepted ManuscriptDOI: 10.1039/C6LC00561F, PaperYujun Song, Yuzhen Wang, wenjin Qi, Ying Li, Jie Xuan, Ping Wang, Lidong QinHere we developed an integrated volumetric bar-chart chip (IV-Chip) technology by integration of our previous V…

Trimethylation Enhancement Using 13C-Diazomethane (13C-TrEnDi): Increased Sensitivity and Selectivity of Phosphatidylethanolamine, Phosphatidylcholine, and Phosphatidylserine Lipids Derived from Complex Biological Samples

Analytical ChemistryDOI: 10.1021/acs.analchem.5b04524

Race Differentiation by Raman Spectroscopy of a Bloodstain for Forensic Purposes

Analytical ChemistryDOI: 10.1021/acs.analchem.6b01173

A New Radio Frequency Plasma Oxygen Primary Ion Source on Nano Secondary Ion Mass Spectrometry for Improved Lateral Resolution and Detection of Electropositive Elements at Single Cell Level

Analytical ChemistryDOI: 10.1021/acs.analchem.6b01153

Highly Efficient Adenoviral Transduction of Pancreatic Islets using a Microfluidic Device

Lab Chip, 2016, Accepted ManuscriptDOI: 10.1039/C6LC00345A, PaperPamuditha N. Silva, Zaid Atto, Romario Regeenes, Uilki Tufa, Yih Yang Chen, Warren Che Wor Chan, Allen Volchuk, Dawn M. Kilkenny, Jonathan V. RocheleauTissues are challenging to genetical…

Identification of Low Abundant Isomeric N-Glycan Structures in Biological Therapeutics by LC/MS

Analytical ChemistryDOI: 10.1021/acs.analchem.6b00636

Systematic approach to optimize a pretreatment method for ultrasensitive liquid chromatography with tandem mass spectrometry analysis of multiple target compounds in biological samples

In current approaches for new drug development, highly sensitive and robust analytical methods for the determination of test compounds in biological samples are essential. These analytical methods should be optimized for every target compound. However…



Capillary electrophoresis coupled with in-column fiber-optic laser-induced fluorescence detection for the rapid separation of neodymium

In the present work, in-column fiber-optic laser-induced fluorescence detection technique is coupled with capillary electrophoresis (CE) for the rapid separation of neodymium for the first time. The effects of buffer concentration, buffer pH, and separation voltage on the CE behaviors, including electrophoretic efficiency and detection sensitivity, are investigated in detail. Under the optimal condition determined in this study (15 mM borate buffer, pH 10.50, separation voltage 24 kV), neodymium could be separated effectively from the neighboring lanthanides (praseodymium and samarium) within several minutes, and the limit of detection for neodymium is estimated to be at the ppt level. The in-column fiber-optic laser-induced fluorescence-capillary electrophoresis (ICFO-LIF-CE) system assembled in this work exhibits unique performance characteristics such as low cost and flexibility. Meanwhile, the separation efficiency and detection sensitivity of the assembled CE system are comparable to or somewhat better than those obtained in the previous traditional CE systems, indicating the potential of the assembled CE system for practical applications in the fields of spent nuclear fuel analysis, nuclear waste disposal/treatment, and nuclear forensics.
This article is protected by copyright. All rights reserved

Optimization of o-phtaldialdehyde/2-mercaptoethanol postcolumn reaction for the hydrophilic interaction liquid chromatography determination of memantine utilizing a silica hydride stationary phase

A rapid procedure for the determination of memantine based on hydrophilic interaction chromatography with fluorescence detection was developed. Fluorescence detection after postcolumn derivatization with o-phtaldialdehyde/2-mercaptoethanol was performed at excitation and emission wavelengths of 345 and 450 nm, respectively. The postcolumn reaction conditions such as reaction temperature, derivatization reagent flow rate and reagents concentration were studied due to steric hindrance of amino group of memantine. The derivatization reaction was applied for the hydrophilic interaction liquid chromatography method which was based on Cogent Silica-C stationary phase with a mobile phase consisting of a mixture of 10 mmol/L citric acid and 10 mmol/L o-phosphoric acid (pH 6.0) with acetonitrile using an isocratic composition of 2:8 v/v. The benefit of the reported approach consists in a simple sample pretreatment and a quick and sensitive hydrophilic interaction chromatography method. The developed method was validated in terms of linearity, accuracy, precision and selectivity according to the International Conference on Harmonisation guidelines. The developed method was successfully applied for the analysis of commercial memantine tablets.
This article is protected by copyright. All rights reserved

Quantitation of Site-Specific Glycosylation in Manufactured Recombinant Monoclonal Antibody Drugs

Analytical ChemistryDOI: 10.1021/acs.analchem.6b00963

Production and Characterization of Monoclonal Antibody Broadly Recognizing Cry1 Toxins by Use of Designed Polypeptide as Hapten

Analytical ChemistryDOI: 10.1021/acs.analchem.6b00429

Synchronized Polarization Induced Electrospray: Comprehensively Profiling Biomolecules in Single Cells by Combining both Positive-Ion and Negative-Ion Mass Spectra

Analytical ChemistryDOI: 10.1021/acs.analchem.6b01490

Full-factorial mapping of light and nutrient levels on photosynthetic productivity

Lab Chip, 2016, Accepted ManuscriptDOI: 10.1039/C6LC00619A, Technical InnovationBrian Nguyen, Percival J Graham, David SintonThis is an Accepted Manuscript, which has been through the RSC Publishing peer review process and has been accepted for publica…

Ultrasound-assisted temperature-controlled ionic liquid dispersive liquid phase microextraction combined with reversed phase liquid chromatography for determination of organophosphorus pesticides in water samples

A rapid and sensitive ultrasound-assisted temperature-controlled ionic liquid dispersive liquid phase microextraction (UTILDLPME) combined with reversed phase liquid chromatography-ultraviolet (RPLC-UV) was developed for the determination of five orga…