On-demand acoustic droplet splitting and steering in a disposable microfluidic chip

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC01083D, PaperJinsoo Park, Jin Ho Jung, Kwangseok Park, Ghulam Destgeer, Husnain Ahmed, Raheel Ahmad, Hyung Jin SungAn acoustofluidic device for on-demand droplet splitting and steering in a disposable mic…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C7LC01083D, Paper
Jinsoo Park, Jin Ho Jung, Kwangseok Park, Ghulam Destgeer, Husnain Ahmed, Raheel Ahmad, Hyung Jin Sung
An acoustofluidic device for on-demand droplet splitting and steering in a disposable microfluidic chip.
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Lab on a Chip in 2017

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC90123B, EditorialThis Editorial summarizes recent news from Lab on a Chip and looks forward to further developments in 2018.To cite this article before page numbers are assigned, use the DOI form of citat…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C7LC90123B, Editorial

This Editorial summarizes recent news from Lab on a Chip and looks forward to further developments in 2018.
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Electrochemical biosensor for cancer cell detection based on surface 3D micro-array

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC01117B, PaperShaoqin Liu, Li An, Guangtong Wang, Yu Han, Tianchan Li, Peng JinThe detection of rare circulating tumour cells (CTCs) in the patients’ blood is crucial for the early diagnosis of cancer…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC01117B, Paper
Shaoqin Liu, Li An, Guangtong Wang, Yu Han, Tianchan Li, Peng Jin
The detection of rare circulating tumour cells (CTCs) in the patients' blood is crucial for the early diagnosis of cancer, highly precise cancer therapy and monitoring the therapeutic outcomes in...
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High-throughput Double Emulsion-based Microfluidic Production of Hydrogel Microspheres with Tunable Chemical Functionalities toward Biomolecular Conjugation

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC01088E, PaperEric Y. Liu, Sukwon Jung, David A. Weitz, Hyunmin Yi, Chang-Hyung ChoiChemically functional hydrogel microspheres hold significant potential in a range of applications including biosensin…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC01088E, Paper
Eric Y. Liu, Sukwon Jung, David A. Weitz, Hyunmin Yi, Chang-Hyung Choi
Chemically functional hydrogel microspheres hold significant potential in a range of applications including biosensing, drug delivery, and tissue engineering due to their high degree of flexibility in imparting a range...
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Multi-size spheroid formation using microfluidic funnels

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00970D, PaperM. Marimuthu, N. Rousset, A. St-Georges-Robillard, M. A. Lateef, M. Ferland, A.-M. Mes-Masson, T. GervaisWe present a microfluidic platform for automatic multi-size spheroid formation within …

Lab Chip, 2018, Advance Article
DOI: 10.1039/C7LC00970D, Paper
M. Marimuthu, N. Rousset, A. St-Georges-Robillard, M. A. Lateef, M. Ferland, A.-M. Mes-Masson, T. Gervais
We present a microfluidic platform for automatic multi-size spheroid formation within constant volume hanging droplets (HDs) from a single inlet loading of a constant cell concentration.
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Cyclic olefin copolymer as an X-ray compatible material for microfluidic devices

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00824D, PaperManuela Denz, Gerrit Brehm, Clement Y. J. Hemonnot, Heidi Spears, Andrew Wittmeier, Chiara Cassini, Oliva Saldanha, Eleonora Perego, Ana Diaz, Manfred Burghammer, Sarah KosterFabrication of X…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C7LC00824D, Paper
Manuela Denz, Gerrit Brehm, Clement Y. J. Hemonnot, Heidi Spears, Andrew Wittmeier, Chiara Cassini, Oliva Saldanha, Eleonora Perego, Ana Diaz, Manfred Burghammer, Sarah Koster
Fabrication of X-ray compatible microfluidic devices by hot embossing, and characterization for small angle X-ray scattering.
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Towards Microwave Imaging of Cells

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC01251A, PaperMehmet Kelleci, Hande Aydogmus, Levent Aslanbas, Selcuk Oguz Erbil, Mehmet Selim HanayIntegrated detection techniques that can provide the morphological properties of cells are needed fo…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC01251A, Paper
Mehmet Kelleci, Hande Aydogmus, Levent Aslanbas, Selcuk Oguz Erbil, Mehmet Selim Hanay
Integrated detection techniques that can provide the morphological properties of cells are needed for the widespread use of lab-on-a-chip technology. Herein, we establish a theoretical and experimental framework to use...
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Cancer immunotherapy [small mu ]-environment LabChip: taking advantage of optoelectronic tweezers

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C7LC00963A, PaperLing-Yi Ke, Zong-Keng Kuo, Yu-Shih Chen, Tsu-Yi Yeh, Minxiang Dong, Hsiang-Wen Tseng, Cheng-Hsien LiuAn OET-based LabChip was developed to provide a stable and static culture [small mu ]-envi…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C7LC00963A, Paper
Ling-Yi Ke, Zong-Keng Kuo, Yu-Shih Chen, Tsu-Yi Yeh, Minxiang Dong, Hsiang-Wen Tseng, Cheng-Hsien Liu
An OET-based LabChip was developed to provide a stable and static culture [small mu ]-environment for cancer immunotherapy studies. The TiOPc-based OET facilitates the studies of cell-cell interaction resulting in apoptotic progress of cancer cells.
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A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement

Lab Chip, 2018, Advance Article
DOI: 10.1039/C7LC00832E, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Andreas R. Thomsen, Christine Aldrian, Peter Bronsert, Yi Thomann, Norbert Nanko, Nicolas Melin, Gerta Rucker, Marie Follo, Anca L. Grosu, Gabriele Niedermann, Paul G. Layer, Anja Heselich, Per G. Lund
Miniaturised conical measures for cell aggregates.
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Lab Chip, 2018, Advance Article
DOI: 10.1039/C7LC00832E, Paper
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Andreas R. Thomsen, Christine Aldrian, Peter Bronsert, Yi Thomann, Norbert Nanko, Nicolas Melin, Gerta Rucker, Marie Follo, Anca L. Grosu, Gabriele Niedermann, Paul G. Layer, Anja Heselich, Per G. Lund
Miniaturised conical measures for cell aggregates.
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Determination of trace polychlorinated biphenyls and organochlorine pesticides in water samples through large-volume stir bar sorptive extraction method with thermal desorption gas chromatography

A fast and sensitive analytical method based on stir bar sorptive extraction technology with gas chromatography and mass spectrometry was developed to simultaneously analyze 18 kinds of polychlorinated biphenyls and 20 kinds of organochlorine pesticides in aqueous samples. A long adsorption time and small sample volume, which are problems encountered in conventional methods of stir bar sorptive extraction, were effectively solved by simultaneously using multiple stir bars for enrichment with sequential cryofocusing and merged injection. Optimized results showed good linear coefficients in the range of 10–500 ng/L and the method detection limits of 0.12–2.07 ng/L for polychlorinated biphenyls and organochlorine pesticides. The recovery ratios of the spiked samples at different concentrations were between 64.7 and 111.0%, and their relative standard deviations ranged from 0.9 to 17.6%. Four types of the studied compounds were determined in Qiantang River water samples, and their contents were between 0.82 and 5.00 ng/L.

Abstract

A fast and sensitive analytical method based on stir bar sorptive extraction technology with gas chromatography and mass spectrometry was developed to simultaneously analyze 18 kinds of polychlorinated biphenyls and 20 kinds of organochlorine pesticides in aqueous samples. A long adsorption time and small sample volume, which are problems encountered in conventional methods of stir bar sorptive extraction, were effectively solved by simultaneously using multiple stir bars for enrichment with sequential cryofocusing and merged injection. Optimized results showed good linear coefficients in the range of 10–500 ng/L and the method detection limits of 0.12–2.07 ng/L for polychlorinated biphenyls and organochlorine pesticides. The recovery ratios of the spiked samples at different concentrations were between 64.7 and 111.0%, and their relative standard deviations ranged from 0.9 to 17.6%. Four types of the studied compounds were determined in Qiantang River water samples, and their contents were between 0.82 and 5.00 ng/L.

Impact of complex surfaces on biomicrorheological measurements using optical tweezers.

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC01176H, PaperShu Zhang, Lachlan Gibson, Alexander Stilgoe, Timo A Nieminen, Halina Rubinsztein-DunlopThe characterisation of physical properties in biologically relevant processes and the development …

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC01176H, Paper
Shu Zhang, Lachlan Gibson, Alexander Stilgoe, Timo A Nieminen, Halina Rubinsztein-Dunlop
The characterisation of physical properties in biologically relevant processes and the development of novel microfluidic devices for this purpose are experiencing a great resurgence at present. In many of measurements...
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