Transient microfluidic compartmentalization using actionable microfilaments for biochemical assays, cell culture and organs-on-chip

Lab Chip, 2016, Accepted ManuscriptDOI: 10.1039/C6LC01143H, PaperAyako Yamada, Renaud Renault, Aleksandra Chikina, Bastien Venzac, Iago Pereiro, Sylvie Coscoy, Marine Verhulsel, Maria Carla Parrini, Catherine Villard, Jean-Louis Viovy, Stephanie Descro…

Spatiotemporal control of kinesin motor protein by photoswitches enabling selective single microtubule regulations

Lab Chip, 2016, Accepted Manuscript
DOI: 10.1039/C6LC01098A, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
K. R. Sunil Kumar, Ammathnadu S. Amrutha, Nobuyuki Tamaoki
An artificial control of bio-nano machines should have a major impact on the development of controllable transport systems for specific cargo transport on chips. Precise spatiotemporal control and local regulation…
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In Situ Molecular Imaging of the Biofilm and Its Matrix

Analytical ChemistryDOI: 10.1021/acs.analchem.6b03909

Adding Biomolecular Recognition Capability to 3D Printed Objects

Analytical ChemistryDOI: 10.1021/acs.analchem.6b03426

Nanopore-Based Selective Discrimination of MicroRNAs with Single-Nucleotide Difference Using Locked Nucleic Acid-Modified Probes

Analytical ChemistryDOI: 10.1021/acs.analchem.6b02620

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

Analytical ChemistryDOI: 10.1021/acs.analchem.6b03109

Enhancement of Compound Selectivity Using a Radio Frequency Ion-Funnel Proton Transfer Reaction Mass Spectrometer: Improved Specificity for Explosive Compounds

Analytical ChemistryDOI: 10.1021/acs.analchem.6b02982

Visual Biopsy by Hydrogen Peroxide-Induced Signal Amplification

Analytical ChemistryDOI: 10.1021/acs.analchem.6b03330

A centrifugal microfluidic device with integrated gold leaf electrodes for the electrophoretic separation of DNA

Lab Chip, 2016, Advance ArticleDOI: 10.1039/C6LC00953K, PaperBrandon L. Thompson, Christopher Birch, Daniel A. Nelson, Jingyi Li, Jacquelyn A. DuVall, Delphine Le Roux, An-Chi Tsuei, Daniel L. Mills, Brian E. Root, James P. LandersA centrifugal microde…

Silver Ion Polyelectrolyte Container as a Sensitive Quartz Crystal Microbalance Gas Detector

Analytical ChemistryDOI: 10.1021/acs.analchem.6b03387

Cell-laden Microfluidic Microgels for Tissue Regeneration

Lab Chip, 2016, Accepted ManuscriptDOI: 10.1039/C6LC01193D, Critical ReviewWeiqian Jiang, Mingqiang Li, Zaozao Chen, Kam LeongRegenerating the diseased tissue is one of the foremost concerns for the millions of patients who suffer from tissue damage ea…

Readily Available Fluorescent Probe for Carbon Monoxide Imaging in Living Cells

Analytical ChemistryDOI: 10.1021/acs.analchem.6b03073

Multiplex pyrosequencing of InDel markers for forensic DNA analysis

The capillary electrophoresis (CE) technology is commonly used for fragment length separation of markers in forensic DNA analysis. In this study, pyrosequencing technology was used as an alternative and rapid tool for the analysis of biallelic InDel (…

Electrochemical Sandwich Immunosensor for Determination of Exosomes Based on Surface Marker-Mediated Signal Amplification

Analytical ChemistryDOI: 10.1021/acs.analchem.6b02421

Biotransformation and metabolic profile of Anemoside B4 with rat small and large intestine microflora by ultra-high performance liquid chromatography-quadrupole time of flight tandem mass spectrometry

Pulsatilla chinensis (Bunge) Regel has been commonly used in Asia, and Anemoside B4 conducted as its major saponin with diverse pharmaceutical effects. Previous studies showed that intestinal flora plays an important role in the metabolism of herbs administered orally. In this study, the metabolic profile of AB4 with microflora in rat small and large intestine in vitro was investigated. Gut microflora was collected from different intestinal segments and anaerobically incubated with AB4 at 37 °C for 24, 48, 72 and 96 h, respectively. A total of 10 metabolites were detected and identified by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry, involving the products of oxygenation and deglycosylation reactions. Gut microflora in the large intestine generated more comprehensive metabolic pathways, which appears to attribute to the wider assortment of bacterial types and amount. Human cancer cell lines SMMC-7721, Hela and MCF-7 were treated with metabolites pool by MTT assay, together with M6 as the most deglycosylation product. As a result, M6 exhibited a reduction in cell viability of SMMC-7721 with an IC50 value of 22.28 ± 1.26 μg/mL. The present study provided scientific evidences for AB4 metabolism in small and large intestine, which is helpful to reveal the active forms of AB4 in vivo. This article is protected by copyright. All rights reserved.

The Midwest Universities Analytical Chemistry Conference: Still the Midwest’s Secret Weapon?

Analytical ChemistryDOI: 10.1021/acs.analchem.6b04076

Cathode Photoelectrochemical Immunosensing Platform Integrating Photocathode with Photoanode

Analytical ChemistryDOI: 10.1021/acs.analchem.6b03473

Motion in microfluidic ratchets

Lab Chip, 2016, Advance ArticleDOI: 10.1039/C6LC90107G, FocusD. Caballero, J. Katuri, J. Samitier, S. SanchezIn this Focus article we discuss recent advances in the use of ratchet-like geometries in microfluidics which could open new avenues in biomedi…

Quick, easy, cheap, effective, rugged, and safe sample preparation approach for pesticide residue analysis using traditional detectors in chromatography- A review

In pesticide residue analysis, relatively low-sensitivity traditional detectors, such as UV, diode array, electron-capture, flame photometric, and nitrogen-phosphorus detectors, have been used following classical sample preparation (liquid–liquid ex…

On-line approaches for the determination of residues and contaminants in complex samples

The determination of residues and contaminants in complex matrices such as in the case of food, environmental and biological samples requires a combination of several steps to succeed in the aimed goal. At least three independent steps are integrated …