A microfluidic microinjector for toxicological and developmental studies in Drosophila embryos

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00537G, PaperReza Ghaemi, Pouya Arefi, Ana Stosic, Meryl Acker, Qanber Raza, Roger Jacobs, Ponnambalam Ravi SelvaganapathyMicroinjection is an established and reliable method to deliver biological rea…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00537G, Paper
Reza Ghaemi, Pouya Arefi, Ana Stosic, Meryl Acker, Qanber Raza, Roger Jacobs, Ponnambalam Ravi Selvaganapathy
Microinjection is an established and reliable method to deliver biological reagents such as transgenic constructs and drugs, to specific locations inside organisms such as the Drosophila embryo and C. elegans...
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Determination of Pore-Scale Hydrate Phase Equilibria in Sediments Using Lab-on-a-Chip Technology

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00719A, PaperStian Almenningen, Josef Flatlandsmo, A. R. Kovscek, Geir Ersland, Martin Anders FernoWe present an experimental protocol for fast determination of hydrate stability in porous media for a…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00719A, Paper
Stian Almenningen, Josef Flatlandsmo, A. R. Kovscek, Geir Ersland, Martin Anders Ferno
We present an experimental protocol for fast determination of hydrate stability in porous media for a range of pressure and temperature (P,T) conditions. Using a lab-on-a-chip approach, we gain direct...
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A Simple Culture System for Long-Term Imaging of Individual C. elegans

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00916J, PaperWill Emmett Pittman, Drew B Sinha, William B Zhang, Holly E Kinser, Zachary PincusWe have miniaturized standard culture techniques to rear arrays of isolated, individual C. elegans throu…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00916J, Paper
Will Emmett Pittman, Drew B Sinha, William B Zhang, Holly E Kinser, Zachary Pincus
We have miniaturized standard culture techniques to rear arrays of isolated, individual C. elegans throughout their lives on solid gel media. The resulting apparatus is compatible with brightfield and fluorescent...
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Confined methane-water interfacial layers and thickness measurements using in situ Raman spectroscopy

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00660H, PaperBruno Pinho, Yukun Liu, Benjamin Rizkin, Ryan L HartmanGas-liquid interfaces broadly impact our planet, yet confined interfaces behave differently than unconfined ones. We report the role…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00660H, Paper
Bruno Pinho, Yukun Liu, Benjamin Rizkin, Ryan L Hartman
Gas-liquid interfaces broadly impact our planet, yet confined interfaces behave differently than unconfined ones. We report the role of tangential fluid motion at confined methane-water interfaces. The interfaces are created...
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Fully chip-embedded automation of a multi-step lab-on-a-chip process using a modularized timer circuit

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00704C, PaperJunsu Kang, Donghyeon Lee, Young Jin Heo, Wan Kyun ChungFor highly-integrated microfluidic systems, an actuation system is necessary to control flow, and the bulk of actuation devices inc…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00704C, Paper
Junsu Kang, Donghyeon Lee, Young Jin Heo, Wan Kyun Chung
For highly-integrated microfluidic systems, an actuation system is necessary to control flow, and the bulk of actuation devices including pumps or valves has impeded broad application of integrated microfluidic systems....
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A Microfluidic Device for Partial Immobilization, Chemical Exposure, and Behavioural Screening of Zebrafish Larvae

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00786H, PaperAsal Nady, Amir Reza Peimani, Georg Zoidl, Pouya RezaiZebrafish larva is an important vertebrate model for sensory-motor integration studies, genetic screening, and drug discovery because…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00786H, Paper
Asal Nady, Amir Reza Peimani, Georg Zoidl, Pouya Rezai
Zebrafish larva is an important vertebrate model for sensory-motor integration studies, genetic screening, and drug discovery because of its excellent characteristics such as optical transparency, genetic manipulability, and genetic similarity...
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Microfluidic diafiltration-on-chip using an integrated magnetic peristaltic micropump

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00954B, PaperJessica F Liu, Sagar Yadavali, Andrew Tsourkas, David IssadoreDiafiltration is a membrane filtration technique that rapidly removes permeable molecules from a solution by controlling the …

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00954B, Paper
Jessica F Liu, Sagar Yadavali, Andrew Tsourkas, David Issadore
Diafiltration is a membrane filtration technique that rapidly removes permeable molecules from a solution by controlling the tangential and orthogonal flows over a membrane and by replenishing the permeate with...
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A microfluidic design to provide stable and uniform in-vitro microenvironment for cell culture inspired by the redundancy characteristic of leaf areole

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00343A, PaperJingmin Li, Juan Wei, Yuanchang Liu, Bo Liu, Tao Liu, Yang Jiang, Laiqian Ding, Chong LiuThe leaf venation is considered to be an optimal transportation system with the mesophyll cells be…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00343A, Paper
Jingmin Li, Juan Wei, Yuanchang Liu, Bo Liu, Tao Liu, Yang Jiang, Laiqian Ding, Chong Liu
The leaf venation is considered to be an optimal transportation system with the mesophyll cells being divided by minor veins into small regions named areoles. The transpiration of water in...
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Isotachophoresis applied to biomolecular reactions

Lab Chip, 2017, Advance ArticleDOI: 10.1039/C7LC00852J, Critical ReviewC. Eid, J. G. SantiagoThis review discusses research developments and applications of isotachophoresis (ITP) to the initiation, control, and acceleration of chemical reactions, emph…

Lab Chip, 2017, Advance Article
DOI: 10.1039/C7LC00852J, Critical Review
C. Eid, J. G. Santiago
This review discusses research developments and applications of isotachophoresis (ITP) to the initiation, control, and acceleration of chemical reactions, emphasizing reactions involving biomolecular reactants such as nucleic acids, proteins, and live cells.
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Customised spatiotemporal temperature gradients created by a liquid metal enabled vortex generator

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00898H, PaperJiu Yang Zhu, Peter Thurgood, Ngan Nguyen, Kamran Ghorbani, Khashayar KhoshmaneshGenerating customised temperature gradients in miniaturised flow-free liquid chambers is challenging due t…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00898H, Paper
Jiu Yang Zhu, Peter Thurgood, Ngan Nguyen, Kamran Ghorbani, Khashayar Khoshmanesh
Generating customised temperature gradients in miniaturised flow-free liquid chambers is challenging due to the dominance of diffusion. Inducing internal flows in the form of vortices is an effective strategy for...
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Inkjet-printed barcodes for rapid and multiplexed paper-based assay compatible with mobile devices

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00780A, PaperMingzhu Yang, Wei Zhang, Wenshu Zheng, fengjing Cao, Xingyu JiangThis study reports a simple, rapid, low-cost, robust, and multiplexed barcoded paper-based assay (BPA) compatible with mob…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00780A, Paper
Mingzhu Yang, Wei Zhang, Wenshu Zheng, fengjing Cao, Xingyu Jiang
This study reports a simple, rapid, low-cost, robust, and multiplexed barcoded paper-based assay (BPA) compatible with mobile devices. Inkjet printer and the XYZ dispensing platform are used to realize mass-manufacturing...
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A tuneable microfluidic system for long duration chemotaxis experiments in a 3D collagen matrix

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00649G, PaperKoceila AIZEL, Andrew G Clark, Anthony Simon, Sara Geraldo, Anette Funfak, Pablo Vargas, Jerome Bibette, Danijela Vignjevic, Nicolas BremondIn many cell types, migration can be oriented t…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00649G, Paper
Koceila AIZEL, Andrew G Clark, Anthony Simon, Sara Geraldo, Anette Funfak, Pablo Vargas, Jerome Bibette, Danijela Vignjevic, Nicolas Bremond
In many cell types, migration can be oriented towards a chemical stimulus. In mammals, for example, embryonic cells migrate to follow developmental cues, immune cells migrate toward sites of inflammation,...
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Microfluidic magnetic bead conveyor belt

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00718C, Paper
Open Access Open Access
Stijn van Pelt, Arjan Frijns, Jaap den Toonder
Magnetic beads play an important role in the miniaturization of clinical diagnostics systems. In lab-on-chip platforms, beads can be made to link to a target species and can then be…
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Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00718C, Paper
Open Access Open Access
Stijn van Pelt, Arjan Frijns, Jaap den Toonder
Magnetic beads play an important role in the miniaturization of clinical diagnostics systems. In lab-on-chip platforms, beads can be made to link to a target species and can then be...
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Enhanced Surface Acoustic Wave Cell Sorting by 3D microfluidic chip design

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00715A, PaperLloyd Ung, Kirk Mutafopulos, Pascal Spink, Richard W Rambach, Thomas Franke, David A. WeitzWe demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of mult…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00715A, Paper
Lloyd Ung, Kirk Mutafopulos, Pascal Spink, Richard W Rambach, Thomas Franke, David A. Weitz
We demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation. We harness the strong vertical component of the...
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Controlled droplet discretization and manipulation using membrane displacement traps

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00910K, PaperSupriya Padmanabhan, Tom Misteli, Don L DeVoeAn innovative platform enabling complex discretization and manipulation of aqueous droplets is described. The system uses simple membrane disp…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00910K, Paper
Supriya Padmanabhan, Tom Misteli, Don L DeVoe
An innovative platform enabling complex discretization and manipulation of aqueous droplets is described. The system uses simple membrane displcement trap elements to perform multuiple functions including droplet discretization, release, metering,...
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On-chip polyelectrolyte coating onto magnetic droplets – Towards continuous flow assembly of drug delivery capsules

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00918F, PaperAli Q Alorabi, Mark Duncan Tarn, Jenifer Gomez-Pastora, Eugenio Bringas, Inmaculada Ortiz, Vesselin N. Paunov, Nicole PammePolyelectrolyte (PE) microcapsules for drug delivery are typical…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00918F, Paper
Ali Q Alorabi, Mark Duncan Tarn, Jenifer Gomez-Pastora, Eugenio Bringas, Inmaculada Ortiz, Vesselin N. Paunov, Nicole Pamme
Polyelectrolyte (PE) microcapsules for drug delivery are typically fabricated via layer-by-layer (LbL) deposition of PE layers of alternating charge on sacrificial template microparticles, which usually requires multiple incubation and washing...
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Self-Sustainable, High-Power-Density Bio-Solar Cells for Lab-on-a-Chip Applications

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00941K, PaperLin Liu, Seokheun ChoiA microfluidic lab-on-a-chip system that generates its own power is essential for stand-alone, independent, self-sustainable point-of-care diagnostic devices to work…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00941K, Paper
Lin Liu, Seokheun Choi
A microfluidic lab-on-a-chip system that generates its own power is essential for stand-alone, independent, self-sustainable point-of-care diagnostic devices to work in limited-resource and remote regions. Miniaturized biological solar cells (or...
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Single cell sequencing: An engineer and business person’s perspective on how we got here

Lab Chip, 2017, Advance ArticleDOI: 10.1039/C7LC90095C, EditorialMark GilliganMicrofluidics entrepreneur Mark Gilligan provides a perspective on the development of single-cell sequencing technologies.To cite this article before page numbers are assigne…

Lab Chip, 2017, Advance Article
DOI: 10.1039/C7LC90095C, Editorial
Mark Gilligan
Microfluidics entrepreneur Mark Gilligan provides a perspective on the development of single-cell sequencing technologies.
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Differential detection photothermal spectroscopy: towards ultra-fast and sensitive label-free detection in picoliter & femtoliter droplets

Lab Chip, 2017, Advance ArticleDOI: 10.1039/C7LC00946A, PaperRichard M. Maceiczyk, David Hess, Flora W. Y. Chiu, Stavros Stavrakis, Andrew J. deMelloDifferential detection photothermal spectroscopy enables ultra-fast and sensitive absorbance quantifica…

Lab Chip, 2017, Advance Article
DOI: 10.1039/C7LC00946A, Paper
Richard M. Maceiczyk, David Hess, Flora W. Y. Chiu, Stavros Stavrakis, Andrew J. deMello
Differential detection photothermal spectroscopy enables ultra-fast and sensitive absorbance quantification in microfluidic droplets.
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Experimental Verification of Simultaneous Desalting and Molecular Preconcentration by Ion Concentration Polarization

Lab Chip, 2017, Accepted ManuscriptDOI: 10.1039/C7LC00857K, PaperWonseok Kim, Sungmin Park, Kihong Kim, Sung Jae KimWhile the ion concentration polarization (ICP) phenomenon has been intensively researched for a last decade, the complete picture of ion…

Lab Chip, 2017, Accepted Manuscript
DOI: 10.1039/C7LC00857K, Paper
Wonseok Kim, Sungmin Park, Kihong Kim, Sung Jae Kim
While the ion concentration polarization (ICP) phenomenon has been intensively researched for a last decade, the complete picture of ions and analytes distributions near the nanoporous membrane has been strongly...
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