Observation of Molecular Self-assembly Events in Massively Parallel Microdroplet Arrays

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00862K, PaperZenon Toprakcioglu, Pavankumar challa, Aviad Levin, Tuomas KnowlesThe self-assembly of peptide and protein molecules into nanoscale filaments is a process associated with both biological …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00862K, Paper
Zenon Toprakcioglu, Pavankumar challa, Aviad Levin, Tuomas Knowles
The self-assembly of peptide and protein molecules into nanoscale filaments is a process associated with both biological function and malfunction. Microfluidic techniques can provide powerful tools in the study of...
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A liver-immune coculture array for predicting systemic drug-induced skin sensitization

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00790J, PaperLOR HUAI CHONG, Huan Li, Isaac Wetzel, Hansang Cho, Yi-Chin TohDrug-induced skin sensitization is prevalent worldwide and can trigger life-threatening health conditions, such as Stevens J…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00790J, Paper
LOR HUAI CHONG, Huan Li, Isaac Wetzel, Hansang Cho, Yi-Chin Toh
Drug-induced skin sensitization is prevalent worldwide and can trigger life-threatening health conditions, such as Stevens Johnson Syndrome. However, existing in vitro skin models cannot adequately predict the skin sensitization effects...
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Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00852C, PaperSiming Lu, Fabio Cuzzucoli, Jing Jiang, Li-Guo Liang, Yimin Wang, Meng-Qi Kong, Xin Zhao, Wenguo Cui, Jun Li, ShuQi WangCancer poses a great health threat to both developed and developing…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00852C, Paper
Siming Lu, Fabio Cuzzucoli, Jing Jiang, Li-Guo Liang, Yimin Wang, Meng-Qi Kong, Xin Zhao, Wenguo Cui, Jun Li, ShuQi Wang
Cancer poses a great health threat to both developed and developing countries, and anti-cancer drugs are of important interest for improved clinical outcomes. Although tumor-on-a-chip technologies offer a feasible approach...
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Measurement and mitigation of free convection in microfluidic gradient generators

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00526E, PaperYang Gu, Varun Hegde, Kyle J.M. BishopMicrofluidic gradient generators are used to study the movement of living cells, lipid vesicles, and colloidal particles in response to spatial varia…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00526E, Paper
Yang Gu, Varun Hegde, Kyle J.M. Bishop
Microfluidic gradient generators are used to study the movement of living cells, lipid vesicles, and colloidal particles in response to spatial variations in their local chemical environment. Such gradient driven...
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Wirelessly activated device with an integrated ionic polymer metal composite (IPMC) cantilever valve for targeted drug delivery

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C8LC00776D, PaperHau Ran Cheong, Nam-Trung Nguyen, Mei Kum Khaw, Boon Yew Teoh, Pei Song CheeA wirelessly activated ionic polymer metal composite (IPMC) releases cisplatin drug from the device’s orifice shows…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00776D, Paper
Hau Ran Cheong, Nam-Trung Nguyen, Mei Kum Khaw, Boon Yew Teoh, Pei Song Chee
A wirelessly activated ionic polymer metal composite (IPMC) releases cisplatin drug from the device's orifice shows decrease of HeLa cell viability with RF turned on.
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High frequency acoustic permeabilisation of drugs through tissue for localised mucosal delivery

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C8LC00355F, PaperShwathy Ramesan, Amgad R. Rezk, Leslie Y. YeoLocalisation of drugs and therapeutic molecules within the mucosa for effective vaccination via a miniature handheld and portable microacoustoflui…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00355F, Paper
Shwathy Ramesan, Amgad R. Rezk, Leslie Y. Yeo
Localisation of drugs and therapeutic molecules within the mucosa for effective vaccination via a miniature handheld and portable microacoustofluidic device.
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Graphene-based biosensor for on-chip detection of Bio-orthogonally Labeled Proteins to Identify the Circulating Biomarkers of Aging during Heterochronic Parabiosis

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00446C, PaperCorinne Marie Sadlowski, Sarah Balderston , Mandeep Sandhu, Reza Hajian, Chao Liu, Thanh-Tra Tran, Michael J. Conboy, Jacobo Paredes, Niren Murthy, Irina M. Conboy, Kiana AranStudies of h…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00446C, Paper
Corinne Marie Sadlowski, Sarah Balderston , Mandeep Sandhu, Reza Hajian, Chao Liu, Thanh-Tra Tran, Michael J. Conboy, Jacobo Paredes, Niren Murthy, Irina M. Conboy, Kiana Aran
Studies of heterochronic parabiosis, where two animals of different ages are joined surgically, provided proof-of-principle results that systemic proteins have broad age-specific effects on tissue health and repair. In an...
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An Integrated Micro-Millifluidic Processing System

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00636A, PaperJiaming Zhang, Qinglei Ji, Ying Liu, Jianyong Huang, Huilin DuanThe development of integrated microfluidic systems/platforms is most concerned in many fields. The present remarkable integ…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00636A, Paper
Jiaming Zhang, Qinglei Ji, Ying Liu, Jianyong Huang, Huilin Duan
The development of integrated microfluidic systems/platforms is most concerned in many fields. The present remarkable integrated system based on stacking multi-layer polydimethylsiloxane (PDMS) requiring complicated fabrications and operations still remain...
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Human stomach-on-a-chip with luminal flow and peristaltic-like motility

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00910D, CommunicationKang Kug Lee, Heather A McCauley, Taylor R. Broda, Matthew J. Kofron, James Wells, Christian I. HongCurrent in vitro approaches and animal models have critical limitations for mod…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00910D, Communication
Kang Kug Lee, Heather A McCauley, Taylor R. Broda, Matthew J. Kofron, James Wells, Christian I. Hong
Current in vitro approaches and animal models have critical limitations for modeling human gastrointestinal diseases because they may not properly represent multicellular human primary tissues. Therefore, there is a need...
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Diffusion–reaction kinetics of microfluidic amperometric biosensors

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C8LC00794B, CommunicationHui Li, Yi Lu, Pak Kin WongA combined experimental and numerical study reveals the dynamics and kinetics of microfluidic amperometric biosensors for bacterial detection.To cite this a…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00794B, Communication
Hui Li, Yi Lu, Pak Kin Wong
A combined experimental and numerical study reveals the dynamics and kinetics of microfluidic amperometric biosensors for bacterial detection.
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Curvature facilitates podocyte culture in a biomimetic platform

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00495A, PaperAnastasia Korolj, Carol Laschinger, Christian H James, Erding Hu, Claire Velikonja, Nathaniel Smith, Irene Gu, Samad Ahadian, Robert N Willette, Milica Radisic, Boyang ZhangMost kidney di…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00495A, Paper
Anastasia Korolj, Carol Laschinger, Christian H James, Erding Hu, Claire Velikonja, Nathaniel Smith, Irene Gu, Samad Ahadian, Robert N Willette, Milica Radisic, Boyang Zhang
Most kidney diseases begin with abnormalities in glomerular podocytes, motivating the need for podocyte models to study pathophysiological mechanisms and new treatment options. However, podocytes cultured in vitro face a...
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An automated in vitro motility assay for high-throughput studies of molecular motors

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00547H, Paper
Open Access Open Access
Till Korten, Elena Tavkin, Lara Scharrel, Vandana Singh Kushwaha, Stefan Diez
Molecular motors, essential to force-generation and cargo transport within cells, are invaluable tools for powering nanobiotechnological lab-on-a-chip devices.
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Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00547H, Paper
Open Access Open Access
Till Korten, Elena Tavkin, Lara Scharrel, Vandana Singh Kushwaha, Stefan Diez
Molecular motors, essential to force-generation and cargo transport within cells, are invaluable tools for powering nanobiotechnological lab-on-a-chip devices.
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Open multi-culture platform for simple and flexible study of multi-cell type interactions

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00560E, Paper
Yasmín R. Álvarez-García, Karla P. Ramos-Cruz, Reinaldo J. Agostini-Infanzón, Loren E. Stallcop, David J. Beebe, Jay W. Warrick, Maribella Domenech
The study of multi-cell-type (MCT) interactions has the potential to significantly impact our understanding of tissue and disease biology.
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Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00560E, Paper
Yasmín R. Álvarez-García, Karla P. Ramos-Cruz, Reinaldo J. Agostini-Infanzón, Loren E. Stallcop, David J. Beebe, Jay W. Warrick, Maribella Domenech
The study of multi-cell-type (MCT) interactions has the potential to significantly impact our understanding of tissue and disease biology.
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Millifluidic culture improves human midbrain organoid vitality and differentiation

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00206A, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Emanuel Berger, Chiara Magliaro, Nicole Paczia, Anna S. Monzel, Paul Antony, Carole L. Linster, Silvia Bolognin, Arti Ahluwalia, Jens C. Schwamborn
The use of millifluidics technology for human midbrain organoid cultures reduces central cell death and increases dopaminergic neuron differentiation.
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Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00206A, Paper
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Emanuel Berger, Chiara Magliaro, Nicole Paczia, Anna S. Monzel, Paul Antony, Carole L. Linster, Silvia Bolognin, Arti Ahluwalia, Jens C. Schwamborn
The use of millifluidics technology for human midbrain organoid cultures reduces central cell death and increases dopaminergic neuron differentiation.
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3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00322J, Paper
Open Access Open Access
Amir R. Aref, Marco Campisi, Elena Ivanova, Andrew Portell, Dalia Larios, Brandon P. Piel, Natasha Mathur, Chensheng Zhou, Raven Vlahos Coakley, Alan Bartels, Michaela Bowden, Zach Herbert, Sarah Hill, Sean Gilhooley, Jacob Carter, Israel Cañadas, Tran C. Thai, Shunsuke Kitajima, Valeria Chiono, Cloud P. Paweletz, David A. Barbie, Roger D. Kamm, Russell W. Jenkins
Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy.
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Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00322J, Paper
Open Access Open Access
Amir R. Aref, Marco Campisi, Elena Ivanova, Andrew Portell, Dalia Larios, Brandon P. Piel, Natasha Mathur, Chensheng Zhou, Raven Vlahos Coakley, Alan Bartels, Michaela Bowden, Zach Herbert, Sarah Hill, Sean Gilhooley, Jacob Carter, Israel Cañadas, Tran C. Thai, Shunsuke Kitajima, Valeria Chiono, Cloud P. Paweletz, David A. Barbie, Roger D. Kamm, Russell W. Jenkins
Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy.
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Microfluidic Affinity Separation Chip for Selective Capture and Release of Label-free Ovarian Cancer Exosomes

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00834E, PaperColin Lee Hisey, Kalpana Deepa Priya Dorayappan, David E Cohn, Selvendiran Karuppaiyah, Derek J. HansfordExosomes are nanoscale vesicles found in many bodily fluids which play a significa…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00834E, Paper
Colin Lee Hisey, Kalpana Deepa Priya Dorayappan, David E Cohn, Selvendiran Karuppaiyah, Derek J. Hansford
Exosomes are nanoscale vesicles found in many bodily fluids which play a significant role in cell-to-cell signaling and contain biomolecules indicative of their cells of origin. Recently, microfluidic devices have...
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Splitting and separation of colloidal streams in sinusoidal microchannels

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00255J, Paper
Mathias Schlenk, Markus Drechsler, Matthias Karg, Walter Zimmermann, Martin Trebbin, Stephan Förster
The control of the distribution of colloidal particles in microfluidic flows plays an important role in biomedical and industrial applications. A particular challenge is to induce cross-streamline migration in laminar…
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Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00255J, Paper
Mathias Schlenk, Markus Drechsler, Matthias Karg, Walter Zimmermann, Martin Trebbin, Stephan Förster
The control of the distribution of colloidal particles in microfluidic flows plays an important role in biomedical and industrial applications. A particular challenge is to induce cross-streamline migration in laminar...
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Lift-off Cell Lithography for Cell Patterning with Clean Background

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00726H, CommunicationCong Wu, Xiongfeng Zhu, Tianxing Man, Pei-Shan Chung, Michael A. Teitell, PY ChiouWe developed a highly efficient method for patterning cells by a novel and simple technique calle…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00726H, Communication
Cong Wu, Xiongfeng Zhu, Tianxing Man, Pei-Shan Chung, Michael A. Teitell, PY Chiou
We developed a highly efficient method for patterning cells by a novel and simple technique called lift-off cell lithography (LCL). Our approach borrows the key concept of lift-off lithography from...
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Multi-parametric cell profiling with a CMOS quad-modality cellular interfacing array for label-free fully automated drug screening

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C8LC00156A, PaperJong Seok Park, Sandra I. Grijalva, Moez K. Aziz, Taiyun Chi, Sensen Li, Michael N. Sayegh, Adam Wang, Hee Cheol Cho, Hua WangA 1024-pixel CMOS quad-modality cellular interfacing array that e…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00156A, Paper
Jong Seok Park, Sandra I. Grijalva, Moez K. Aziz, Taiyun Chi, Sensen Li, Michael N. Sayegh, Adam Wang, Hee Cheol Cho, Hua Wang
A 1024-pixel CMOS quad-modality cellular interfacing array that enables multi-parametric cell profiling and holistic cellular characterization for drug development.
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A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C. elegans

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00655E, PaperSahand Saberi-Bosari, Javier Huayta, Adriana San-MiguelAging produces a number of changes in neuronal structure and function throughout a variety of organisms. These aging-induced changes…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00655E, Paper
Sahand Saberi-Bosari, Javier Huayta, Adriana San-Miguel
Aging produces a number of changes in neuronal structure and function throughout a variety of organisms. These aging-induced changes encompass a wide range of phenotypes, from loss of locomotion ability...
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