Dynamic Monitoring of Transmembrane Potential Changes: Study of Ion Channels using Electrical Double Layer gated FET Biosensor

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01305A, PaperAnil Kumar Pulikkathodi, Indu Sarangadharan, Yi-Hong Chen, Geng-Yen Lee, Jen-Inn Chyi, Gwo-Bin Lee, Yu-Lin WangIn this research, we have designed, fabricated and characterized electrical …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01305A, Paper
Anil Kumar Pulikkathodi, Indu Sarangadharan, Yi-Hong Chen, Geng-Yen Lee, Jen-Inn Chyi, Gwo-Bin Lee, Yu-Lin Wang
In this research, we have designed, fabricated and characterized electrical double layer (EDL) gated AlGaN/GaN High electron mobility transistor (HEMT) biosensor array to study the transmembrane potential changes of cells....
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Flow dynamics control endothelial permeability in a microfluidic vessel bifurcation model

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00130H, PaperEhsan Akbari, Griffin B. Spychalski, Kaushik k Rangharajan, Shaurya Prakash, Jonathan W. SongEndothelial barrier function is known to be regulated by a number of molecular mechanisms; ho…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00130H, Paper
Ehsan Akbari, Griffin B. Spychalski, Kaushik k Rangharajan, Shaurya Prakash, Jonathan W. Song
Endothelial barrier function is known to be regulated by a number of molecular mechanisms; however, the role of biomechanical signals associated with blood flow is comparatively less explored. Biomimetic microfluidic...
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Quantifying orientational regeneration of injured neurons by natural products concentration gradients in a 3D microfluidic device

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01143A, PaperYun Tang, Quan-Fa Qiu, Fu-Li Zhang, Min Xie, Wei-Hua HuangRegeneration of injured neurons in complicated three-dimensional (3D) microenvironment is a key approach for treating neurodegene…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01143A, Paper
Yun Tang, Quan-Fa Qiu, Fu-Li Zhang, Min Xie, Wei-Hua Huang
Regeneration of injured neurons in complicated three-dimensional (3D) microenvironment is a key approach for treating neurodegenerative disease. Microfluidics provides a versatile tool to recapitulate cellular microenvironment in vitro, but it...
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Flow induced dissolution of femtoliter surface droplet arrays

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01321C, PaperLei Bao, Vamsi Spandan, Yantao Yang, Brendan Dyett, Roberto Verzicco, Detlef Lohse, Xuehua ZhangThe dissolution of liquid nanodroplets is a crucial step in many applied processes, such as…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01321C, Paper
Lei Bao, Vamsi Spandan, Yantao Yang, Brendan Dyett, Roberto Verzicco, Detlef Lohse, Xuehua Zhang
The dissolution of liquid nanodroplets is a crucial step in many applied processes, such as separation and dispersion in food industry, crystal formation of pharmaceutical products, concentrating and analysis in...
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Colloidal lithography-based fabrication of highly-ordered nanofluidic channels with an ultra-high surface-to-volume ratio

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01326D, PaperShuli Wang, Yongshun Liu, Peng Ge, Qiqi Kan, Nianzuo Yu, Jing Wang, Jingjie Nan, Shunsheng Ye, Junhu Zhang, Weiqing Xu, Bai YangThis article shows a new strategy for the fabrication of na…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01326D, Paper
Shuli Wang, Yongshun Liu, Peng Ge, Qiqi Kan, Nianzuo Yu, Jing Wang, Jingjie Nan, Shunsheng Ye, Junhu Zhang, Weiqing Xu, Bai Yang
This article shows a new strategy for the fabrication of nanofluidics based on nanoscale gaps in nanopillar arrays. Silicon nanopillar arrays are prepared in designed position by combining conventional photolithography...
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Entropic trap purification of long DNA

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01355H, PaperPranav Agrawal, Zsofia Bognar, Kevin DorfmanLong-read genomic applications, such as genome mapping in nanochannels, require long DNA that is free of small-DNA impurities. We have develope…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01355H, Paper
Pranav Agrawal, Zsofia Bognar, Kevin Dorfman
Long-read genomic applications, such as genome mapping in nanochannels, require long DNA that is free of small-DNA impurities. We have developed a chip-based system based on entropic trapping that can...
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Lateral Flow Assay with Pressure Meter Readout for Rapid Point-of-care Detection of Disease-associated Protein

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00010G, PaperBingqian Lin, Zhichao Guan, Yanling Song, Eunyeong Song, Zifei Lu, Dan Liu, Yuan An, Zhi Zhu, Leiji Zhou, Chaoyong James YangPaper-based assays such as lateral flow assays are good cand…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00010G, Paper
Bingqian Lin, Zhichao Guan, Yanling Song, Eunyeong Song, Zifei Lu, Dan Liu, Yuan An, Zhi Zhu, Leiji Zhou, Chaoyong James Yang
Paper-based assays such as lateral flow assays are good candidates for portable diagnostic owing to their user-friendly format and low cost. In terms of analytical detection, the lateral flow assays...
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A planar impedance sensor for 3D spheroids

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00067K, PaperVincenzo Curto, Magali Ferro, Federica Mariani, Erika Scavetta, Roisin OwensThree dimensional cell culture systems have witnessed rapid expansion in the fields of tissue engineering and d…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00067K, Paper
Vincenzo Curto, Magali Ferro, Federica Mariani, Erika Scavetta, Roisin Owens
Three dimensional cell culture systems have witnessed rapid expansion in the fields of tissue engineering and drug testing owing to their inherent ability to mimic native tissue microenvironments. High throughput...
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Microfluidic label-free selection of mesenchymal stem cell subpopulation during culture expansion extends the chondrogenic potential in vitro

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01005B, PaperLu Yin, Yingnan Wu, Zheng Yang, Ching Ann Tee, Vinitha Denslin, Zhangxing Lai, Chwee Teck Lim, Eng Hin Lee, Jongyoon HanMesenchymal stem cells (MSCs) have been shown as potential candidat…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01005B, Paper
Lu Yin, Yingnan Wu, Zheng Yang, Ching Ann Tee, Vinitha Denslin, Zhangxing Lai, Chwee Teck Lim, Eng Hin Lee, Jongyoon Han
Mesenchymal stem cells (MSCs) have been shown as potential candidates for cell-based therapies for a diverse range of tissue regenerative applications. Therapeutic use of MSCs usually requires culture expansion, which...
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In-situ photo-patterning of pressure-resistant hydrogel membranes with controlled permeabilities in PEGDA microfluidic channels

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01342F, PaperJeremy Decock, Mathias Schlenk, Jean-Baptiste SalmonWe report the fabrication of highly permeable membranes in poly(ethylene glycol) diacrylate (PEGDA) channels, for investigating ultra- …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01342F, Paper
Jeremy Decock, Mathias Schlenk, Jean-Baptiste Salmon
We report the fabrication of highly permeable membranes in poly(ethylene glycol) diacrylate (PEGDA) channels, for investigating ultra- or micro-filtration, at the microfluidic scale. More precisely, we use a maskless UV...
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AMPLIFICATION-FREE DETECTION OF DNA IN A PAPER-BASED MICROFLUIDIC DEVICE USING ELECTROOSMOTICALLY BALANCED ISOTACHOPHORESIS

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01250K, PaperTally Rosenfeld, Moran BercoviciWe present a novel microfluidic paper-based analytical device ([small mu ]PAD) which utilizes the native high electroosmotic flow (EOF) in nitrocellulose t…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01250K, Paper
Tally Rosenfeld, Moran Bercovici
We present a novel microfluidic paper-based analytical device ([small mu ]PAD) which utilizes the native high electroosmotic flow (EOF) in nitrocellulose to achieve stationary isotachophoresis (ITP) focusing. This approach decouples sample accumulation...
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Injection molded lab on disc platform for screening of genetically modified E. coli using liquid-liquid extraction and surface enhanced Raman scattering

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01217A, PaperLidia Morelli, Laura Serioli, Francesca Alessandra Centorbi, Christian Bille Jendresen, Marco Matteucci, Oleksii Ilchenko, Danilo Demarchi, Alex Toftgaard Nielsen, Kinga Zor, Anja Boisen…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01217A, Paper
Lidia Morelli, Laura Serioli, Francesca Alessandra Centorbi, Christian Bille Jendresen, Marco Matteucci, Oleksii Ilchenko, Danilo Demarchi, Alex Toftgaard Nielsen, Kinga Zor, Anja Boisen
We present the development of an automated centrifugal microfluidic platform with integrated sample pre-treatment (filtration and liquid-liquid extraction) and detection (SERS-based sensing). The platform consists of eight calibration and four...
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Real-time multiplexed PCR using surface enhanced Raman spectroscopy in a thermoplastic chip

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01227F, PaperStephen M. Restaino, Ian Matthew WhiteSurface enhanced Raman spectroscopy (SERS) has the potential to be applied across the spectrum of chemical and biological sensing in the field or at …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01227F, Paper
Stephen M. Restaino, Ian Matthew White
Surface enhanced Raman spectroscopy (SERS) has the potential to be applied across the spectrum of chemical and biological sensing in the field or at the point of care. In diagnostic...
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X-ray Transparent Microfluidic Platforms for Membrane Protein Crystallization with Microseeds

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01141E, PaperJeremy Schieferstein, Ashtamurthy Pawate, Michael Varel, Sudipto Guha, leva Astrauskaite, Robert Bob Gennis, Paul KenisCrystallization of membrane proteins is a critical step for uncoveri…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01141E, Paper
Jeremy Schieferstein, Ashtamurthy Pawate, Michael Varel, Sudipto Guha, leva Astrauskaite, Robert Bob Gennis, Paul Kenis
Crystallization of membrane proteins is a critical step for uncovering atomic resolution 3-D structures and elucidating the structure-function relationship. Microseeding, the process of transferring sub-microscopic crystal nuclei from initial screens...
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Pulsatile plasma filtration and cell-free DNA amplification using water-head-driven point-of-care testing chip

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01328K, PaperYonghun Lee, Dong-Min Kim, Zhenglin Li, Dong-Eun Kim, Sung-Jin KimWe demonstrate a microfiltration chip that separates blood plasma by using water-head-driven pulsatile pressures rather…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01328K, Paper
Yonghun Lee, Dong-Min Kim, Zhenglin Li, Dong-Eun Kim, Sung-Jin Kim
We demonstrate a microfiltration chip that separates blood plasma by using water-head-driven pulsatile pressures rather than any external equipment and use it for on-chip amplification of nucleic acids. The chip...
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Integrated Dual-Modality Microfluidic Sensor for Biomarker Detection Using Lithographic Plasmonic Crystal

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01211J, PaperMd Azahar Ali, shawana tabassum, Qiugu Wang, Yifei Wang, Ratnesh Kumar, Liang DongThis paper reports an integrated dual-modality microfluidic sensor chip, consisting of a patterned period…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01211J, Paper
Md Azahar Ali, shawana tabassum, Qiugu Wang, Yifei Wang, Ratnesh Kumar, Liang Dong
This paper reports an integrated dual-modality microfluidic sensor chip, consisting of a patterned periodic array of nanoposts coated with gold (Au) and graphene oxide (GO), to detect target biomarker molecules...
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Human brain organoid-on-a-chip to model prenatal nicotine exposure

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01084B, PaperJianhua Qin, Yaqing Wang, Li Wang, Yujuan ZhuNicotine has been recognized to trigger various neuronal disabilities in the fetal brain and long-lasting behavioral deficits in offspring. Ho…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01084B, Paper
Jianhua Qin, Yaqing Wang, Li Wang, Yujuan Zhu
Nicotine has been recognized to trigger various neuronal disabilities in the fetal brain and long-lasting behavioral deficits in offspring. However, further understanding of fetal brain development under nicotine exposure is...
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Impedance based real-time position sensor for Lab-On-a-Chip devices.

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01344B, PaperBenoit Brazey, Jonathan COTTET, Aude Bolopion, Harald van Lintel, Philippe Renaud, Michael GauthierThis paper presents the theoretical and experimental development of an integrated positi…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01344B, Paper
Benoit Brazey, Jonathan COTTET, Aude Bolopion, Harald van Lintel, Philippe Renaud, Michael Gauthier
This paper presents the theoretical and experimental development of an integrated position sensor for Lab-On-a-Chip devices. The interest for single cell analysis is growing. However this requires to monitor and...
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Light-responsive Polymers for Microfluidic Applications

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01297G, Critical ReviewJeroen ter Schiphorst, Janire Saez, Dermot Diamond, Fernando Benito-Lopez, Albert SchenningWhile the microfluidic device itself may be small, often the equipment required to con…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01297G, Critical Review
Jeroen ter Schiphorst, Janire Saez, Dermot Diamond, Fernando Benito-Lopez, Albert Schenning
While the microfluidic device itself may be small, often the equipment required to control fluidics in the chip unit is large e.g. pumps, valves and mixing units, which can severely...
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Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C7LC01223C, PaperLuis Ruben Soenksen Martinez, Timothy Kassis, Minkyun Noh, Linda G Griffith, David L TrumperPrecise fluid height sensing in open-channel microfluidics has long been a desirable feature fo…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C7LC01223C, Paper
Luis Ruben Soenksen Martinez, Timothy Kassis, Minkyun Noh, Linda G Griffith, David L Trumper
Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications. However, performing accurate measurements of the fluid level in small-scale reservoirs...
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