An acoustofluidic trap and transfer approach for organizing a high density single cell array

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C8LC00196K, PaperKorine A. Ohiri, Sean T. Kelly, Jeffrey D. Motschman, Kevin H. Lin, Kris C. Wood, Benjamin B. YellenWe demonstrate a hybrid microfluidic system that combines fluidic trapping and acoustic swi…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00196K, Paper
Korine A. Ohiri, Sean T. Kelly, Jeffrey D. Motschman, Kevin H. Lin, Kris C. Wood, Benjamin B. Yellen
We demonstrate a hybrid microfluidic system that combines fluidic trapping and acoustic switching to organize an array of single cells at high density.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Crystal-on-crystal chips for in situ serial diffraction at room temperature

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00489G, PaperZhong Ren, Medine Ayhan, Sepalika Bandara, Kalinga Bowatte, Indika Kumarapperuma, Semini Gunawardana, Heewhan Shin, Cong Wang, Xiaoli Zeng, Xiaojing YangRecent developments in serial crys…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00489G, Paper
Zhong Ren, Medine Ayhan, Sepalika Bandara, Kalinga Bowatte, Indika Kumarapperuma, Semini Gunawardana, Heewhan Shin, Cong Wang, Xiaoli Zeng, Xiaojing Yang
Recent developments in serial crystallography at X-ray free electron lasers (XFELs) and synchrotrons have been driven by two scientific goals in structural biology - first, static structure determination from nano...
The content of this RSS Feed (c) The Royal Society of Chemistry

Surface acoustic wave diffraction driven mechanisms in microfluidic systems

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00243F, PaperArmaghan Fakhfouri, Citsabehsan Devendran, Thomas Albrecht, David John Collins, Andreas Winkler, Hagen Schmidt, Adrian NeildAcoustic forces arising from high-frequency surface acoustic wa…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00243F, Paper
Armaghan Fakhfouri, Citsabehsan Devendran, Thomas Albrecht, David John Collins, Andreas Winkler, Hagen Schmidt, Adrian Neild
Acoustic forces arising from high-frequency surface acoustic waves (SAW) underpin an exciting range of promising techniques for non-contact manipulation of fluid and objects at micron scale. Despite increasing significance of...
The content of this RSS Feed (c) The Royal Society of Chemistry

Micro/nano acoustofluidics: materials, phenomena, design, devices, and applications

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C8LC00112J, Critical ReviewWilliam Connacher, Naiqing Zhang, An Huang, Jiyang Mei, Shuai Zhang, Tilvawala Gopesh, James FriendAcoustic actuation of fluids at small scales may finally enable a comprehensive la…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00112J, Critical Review
William Connacher, Naiqing Zhang, An Huang, Jiyang Mei, Shuai Zhang, Tilvawala Gopesh, James Friend
Acoustic actuation of fluids at small scales may finally enable a comprehensive lab-on-a-chip revolution in microfluidics, overcoming long-standing difficulties in fluid and particle manipulation on-chip.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Low-power, low-cost urinalysis system with integrated dipstick evaluation and microscopic analysis

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00501J, PaperGennifer T. Smith, Linkai Li, Yue Zhu, Audrey K. BowdenWe introduce a coupled dipstick and microscopy device for analyzing urine samples. The device is capable of accurately assessing uri…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00501J, Paper
Gennifer T. Smith, Linkai Li, Yue Zhu, Audrey K. Bowden
We introduce a coupled dipstick and microscopy device for analyzing urine samples. The device is capable of accurately assessing urine dipstick results while simultaneously imaging the microscopic contents within the...
The content of this RSS Feed (c) The Royal Society of Chemistry

3D cell electrorotation and imaging for measuring multiple cellular biophysical properties

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00407B, PaperLiang Huang, Peng Zhao, Wenhui Wang3D rotation is one of many fundamental manipulations to cells and imperative in a wide range of applications in single cell analysis involving biology, …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00407B, Paper
Liang Huang, Peng Zhao, Wenhui Wang
3D rotation is one of many fundamental manipulations to cells and imperative in a wide range of applications in single cell analysis involving biology, chemistry, physics and medicine. In this...
The content of this RSS Feed (c) The Royal Society of Chemistry

Static droplet array for culturing single live adherent cells in an isolated chemical microenvironment

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00403J, PaperAmin Hassanzadeh-Barforoushi, Andrew Law, Abbas Hejri, Mohsen Asadnia, David Gallego-Ortega, Christopher Ormandy, Majid Ebrahimi WarkianiWe present here a new method to easily and reli…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00403J, Paper
Amin Hassanzadeh-Barforoushi, Andrew Law, Abbas Hejri, Mohsen Asadnia, David Gallego-Ortega, Christopher Ormandy, Majid Ebrahimi Warkiani
We present here a new method to easily and reliably generate an array of hundreds of dispersed nanoliter-volume semi-droplets for single-cells culture and analysis. The liquid segmentation step occurs directly...
The content of this RSS Feed (c) The Royal Society of Chemistry

User-defined local stimulation of live tissue through a movable microfluidic port

Lab Chip, 2018, Advance ArticleDOI: 10.1039/C8LC00204E, PaperMegan A. Catterton, Austin F. Dunn, Rebecca R. PompanoA two-component, two-phase microfluidic device provides a movable port for user-selectable local stimulation of living tissue slices.To c…

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00204E, Paper
Megan A. Catterton, Austin F. Dunn, Rebecca R. Pompano
A two-component, two-phase microfluidic device provides a movable port for user-selectable local stimulation of living tissue slices.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Anti-thrombotic strategies for microfluidic blood processing

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00035B, PaperKeith Wong, Jon Edd, Shannon Tessier, Will D. Moyo, Baris Mutlu, Lauren D. Bookstaver, Kathleen L. Miller, Stefan Herrara, Shannon L. Stott, Mehmet TonerThe redundant mechanisms involved …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00035B, Paper
Keith Wong, Jon Edd, Shannon Tessier, Will D. Moyo, Baris Mutlu, Lauren D. Bookstaver, Kathleen L. Miller, Stefan Herrara, Shannon L. Stott, Mehmet Toner
The redundant mechanisms involved in blood coagulation are crucial for rapid hemostasis. Yet they also create challenges in blood processing in medical devices and lab-on-a-chip systems. In this work, we...
The content of this RSS Feed (c) The Royal Society of Chemistry

A high-throughput multi-microfluidic crystal generator (MMicroCryGen) platform for facile screening of polymorphism and crystals morphology for pharmaceutical compounds

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00301G, PaperElena Simone, James McVeigh, Nuno M Reis, Zoltan NagyIn this work a novel multi-microfluidic crystallization platform called MMicroCryGen is presented, enabling the generation of single c…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00301G, Paper
Elena Simone, James McVeigh, Nuno M Reis, Zoltan Nagy
In this work a novel multi-microfluidic crystallization platform called MMicroCryGen is presented, enabling the generation of single crystals and fast and easy screening for polymorphism and crystal habit of solid...
The content of this RSS Feed (c) The Royal Society of Chemistry

Dynamic CTC Phenotypes in Prostate Cancer Metastatic Models Visualized Using Magnetic Ranking Cytometry

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00310F, PaperLeyla Kermanshah, Mahla Poudineh, Sharif Ahmed, Luan Matthew Nguyen, Sanjana Srikant, Rhema Makonnen, Fernando Pena Cantu, Micheal Corrigan, Shana O KelleyTumors can shed thousands of cel…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00310F, Paper
Leyla Kermanshah, Mahla Poudineh, Sharif Ahmed, Luan Matthew Nguyen, Sanjana Srikant, Rhema Makonnen, Fernando Pena Cantu, Micheal Corrigan, Shana O Kelley
Tumors can shed thousands of cells into the circulation daily. These circulating tumor cells (CTCs) are heterogeneous, and their phenotypes change dynamically. Real-time monitoring of CTC phenotypes is crucial to...
The content of this RSS Feed (c) The Royal Society of Chemistry

Microfluidics-enabled rational design of immunomagnetic nanomaterial and its shape effect in liquid biopsy

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00273H, CommunicationNanjing Hao, Yuan Nie, Ting Shen, John X. J. ZhangMicrofluidics brings unique opportunities for nanomaterials synthesis toward efficient liquid biopsy. Herein, we developed micror…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00273H, Communication
Nanjing Hao, Yuan Nie, Ting Shen, John X. J. Zhang
Microfluidics brings unique opportunities for nanomaterials synthesis toward efficient liquid biopsy. Herein, we developed microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply...
The content of this RSS Feed (c) The Royal Society of Chemistry

A rapid and eco-friendly isothermal amplification microdevice for multiplex detection of foodborne pathogens

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00424B, PaperThi Ngoc Diep Trinh, Nae Yoon LeeIn this study, a plastic microdevice based on loop-mediated isothermal amplification (LAMP) was fabricated for the amplification and on-chip fluorescence …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00424B, Paper
Thi Ngoc Diep Trinh, Nae Yoon Lee
In this study, a plastic microdevice based on loop-mediated isothermal amplification (LAMP) was fabricated for the amplification and on-chip fluorescence detection of multiple pathogens. Papers infused with LAMP reagents and...
The content of this RSS Feed (c) The Royal Society of Chemistry

Feedback Control for Defect-free Alignment of Colloidal Particles

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00369F, PaperYu Gao, Richard LakerveldPrecise alignment of small-scale building blocks into specific structural features is important for the manufacture of novel materials. Directed self-assembly is …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00369F, Paper
Yu Gao, Richard Lakerveld
Precise alignment of small-scale building blocks into specific structural features is important for the manufacture of novel materials. Directed self-assembly is a promising route to align such small-scale building blocks...
The content of this RSS Feed (c) The Royal Society of Chemistry

Pneumatic microfluidic cell compression device for high-throughput study of chondrocyte mechanobiology

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00320C, PaperDonghee Lee, Alek G. Erickson, Taesun You, Andrew T. Dudley, Sangjin RyuHyaline cartilage is a specialized type of connective tissue that lines many moveable joints (articular cartilage) …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00320C, Paper
Donghee Lee, Alek G. Erickson, Taesun You, Andrew T. Dudley, Sangjin Ryu
Hyaline cartilage is a specialized type of connective tissue that lines many moveable joints (articular cartilage) and contributes to bone growth (growth plate cartilage). Hyaline cartilage is composed of a...
The content of this RSS Feed (c) The Royal Society of Chemistry

NemaFlex: A microfluidics-based technology for standardized measurement of muscular strength of C. elegans

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00103K, PaperMizanur Rahman, Jennifer Hewitt, Frank Van-Bussel, Hunter Edwards, Jerzy Blawzdziewicz, Nathaniel Szewczyk, Monica Driscoll, Siva A VanapalliMuscle strength is a functional measure of qua…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00103K, Paper
Mizanur Rahman, Jennifer Hewitt, Frank Van-Bussel, Hunter Edwards, Jerzy Blawzdziewicz, Nathaniel Szewczyk, Monica Driscoll, Siva A Vanapalli
Muscle strength is a functional measure of quality of life in humans. Declines in muscle strength are manifested in diseases as well as during inactivity, aging, and space travel. With...
The content of this RSS Feed (c) The Royal Society of Chemistry

Additive Manufacturing of Three-dimensional (3D) Microfluidic-based Microelectromechanical Systems (MEMS) for Acoustofluidic Applications

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00427G, PaperEllen Cesewski, Alexander P. Haring, Yuxin Tong, Manjot Singh, Rajan Thakur, Sahil Laheri, Kaitlin A. Read, Michael D. Powell, Kenneth J. Oestreich, Blake N. JohnsonThree-dimensional (…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00427G, Paper
Ellen Cesewski, Alexander P. Haring, Yuxin Tong, Manjot Singh, Rajan Thakur, Sahil Laheri, Kaitlin A. Read, Michael D. Powell, Kenneth J. Oestreich, Blake N. Johnson
Three-dimensional (3D) printing now enables the fabrication of novel 3D structural electronics and microfluidics. However, conventional subtractive manufacturing processes for MEMS fabrication relatively limit device structure to two dimensions and...
The content of this RSS Feed (c) The Royal Society of Chemistry

Sequencing of human genomes extracted from single cancer cells isolated in a valveless microfluidic device

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00169C, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rodolphe Marie, Marie Podenphant, Kamila Koprowska, Loic Baerlocher, Rolan C. M. Vulders, Jennifer Wilding, Neil Ashley, Simon J. McGowan, Dianne van Strijp, Freek van Hemert, Tom Olesen, Niels Agersnap, Brian Bilenberg, Celine Sabatel, Julien Schira, Anders Kristensen, Walter Bodmer, Pieter J. van der Zaag, Kalim U. Mir
Whole genome sequencing of single cancer cells isolated and lysed in an injection-moulded valveless microfluidic device.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

Lab Chip, 2018, Advance Article
DOI: 10.1039/C8LC00169C, Paper
Open Access Open Access
Creative Commons Licence  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rodolphe Marie, Marie Podenphant, Kamila Koprowska, Loic Baerlocher, Rolan C. M. Vulders, Jennifer Wilding, Neil Ashley, Simon J. McGowan, Dianne van Strijp, Freek van Hemert, Tom Olesen, Niels Agersnap, Brian Bilenberg, Celine Sabatel, Julien Schira, Anders Kristensen, Walter Bodmer, Pieter J. van der Zaag, Kalim U. Mir
Whole genome sequencing of single cancer cells isolated and lysed in an injection-moulded valveless microfluidic device.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00236C, PaperXiaolin Wang, Da Zhao, Duc T. T. Phan, Jing-Quan Liu, Xiang Chen, Bin Yang, Christopher Hughes, Weijia Zhang, Abraham LeeAutonomous and self-powered micropumps are in critical demand for …

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00236C, Paper
Xiaolin Wang, Da Zhao, Duc T. T. Phan, Jing-Quan Liu, Xiang Chen, Bin Yang, Christopher Hughes, Weijia Zhang, Abraham Lee
Autonomous and self-powered micropumps are in critical demand for versatile cell- and tissue-based applications as well as for low-cost point-of-care testing (POCT) in microfluidics fields. The hydrostatic pressure-driven passive micropumps...
The content of this RSS Feed (c) The Royal Society of Chemistry

Microfluidic nozzle device for ultrafine fiber solution blow spinning with precise diameter control

Lab Chip, 2018, Accepted ManuscriptDOI: 10.1039/C8LC00304A, PaperEddie Hofmann, Kilian Kruger, Christian Haynl, Thomas Scheibel, Martin Trebbin, Stephan ForsterWe present a microfluidic nozzle device for the controlled continuous solution blow spinning…

Lab Chip, 2018, Accepted Manuscript
DOI: 10.1039/C8LC00304A, Paper
Eddie Hofmann, Kilian Kruger, Christian Haynl, Thomas Scheibel, Martin Trebbin, Stephan Forster
We present a microfluidic nozzle device for the controlled continuous solution blow spinning of ultrafine fibers. The device is fabricated by soft lithography techniques and is based on the principle...
The content of this RSS Feed (c) The Royal Society of Chemistry